Juvenile myelomonocytic leukemia with t(7;11)(p15;p15) andNUP98-HOXA11fusion
نویسندگان
چکیده
منابع مشابه
Juvenile myelomonocytic leukemia.
A was less than 4 years, with any type of myelodysplasia and monosomy 7. All other patients, including older children BOUT 40 YEARS ago two forms of chronic myelocytic leukemia (CML) were recognized in children. One had the typical features of CML of adulthood and usually with monosomy 7, were classified according to FAB criteria. The revised classification led the authors to propose a new appe...
متن کاملPEDIATRIC HEMATOLOGY Juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is a rare clonal myeloproliferative disorder (MPD) of early childhood [1]. The median age at diagnosis is 2 years [1]. There is a male predominance with a male:female ratio of 2:1. Pallor, fever, infection, skin bleeding and cough are the most common presenting symptoms. Typically, there is marked hepatosplenomegaly. JMML rarely involves the central nervo...
متن کاملJuvenile myelomonocytic leukemia and Noonan syndrome.
A case of juvenile myelomonocytic leukemia (JMML, previously referred to as JCML) in a neonate with Noonan syndrome (NS) is described. The boy presented with bilateral congenital hydrothoraces, nonimmune hydrops, dysmorphic facies, persistent thrombocytopenia, and leukocytosis. The diagnosis of JMML was made on bone marrow cell culture studies. Review of the literature reveals an unusual prepon...
متن کاملDifferentiating juvenile myelomonocytic leukemia from infectious disease.
1. Bernardi F, Faioni EM, Castoldi E, Lunghi B, Castaman G, Sacchi E, Mannucci PM: A factor V genetic component differing from Factor V R506Q contributes to the activated protein C resistance phenotype. Blood 90:1552, 1997 2. Lunghi B, Iacoviello L, Gemmati D, di Iasio MG, Castoldi E, Pinotti M, Castaman G, Redaelli R, Mariani G, Marchetti G, Bernardi F: Detection of new polymorphic markers in ...
متن کاملMolecular basis of juvenile myelomonocytic leukemia.
haematologica | 2010; 95(2) 179 Juvenile myelomonocytic leukemia (JMML) is classified as a combined myeloproliferative/ myelodysplastic disease by the World Health Organization and accounts for less than 3% of all childhood hematologic malignancies. Children typically present at young age (median age at diagnosis: two years) with hepatosplenomegaly, monocytosis, anemia, thrombocytopenia and ele...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2009
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.21373